SET-LRP of N-(2-hydroxypropyl)methacrylamide in H2O

Cu(0) wire-catalyzed SET-LRP of N-(2-hydroxypropyl)methacrylamide (HPMA) initiated with methyl 2-chloropropionate (MCP) in H2O at 50 °C exhibited linear kinetics up to 90% conversion using 0.5 equivalents of Me6-TREN with respect to initiator concentration.