化学
吗啉
食腐动物
烷基化
保护组
小学(天文学)
固相合成
有机化学
钯
组合化学
催化作用
激进的
烷基
生物化学
肽
天文
物理
作者
Dolors Fernández-Forner,Gaspar Casals,Eloı́sa Navarro,Hamish Ryder,Fernando Alberício
标识
DOI:10.1016/s0040-4039(01)00755-9
摘要
A useful method for Alloc removal from secondary amines on solid-phase has been optimised. The use of Me2NH·BH3 (40 equiv., 40 min) as scavenger of the allyl cations in a palladium-catalysed process with Pd[PPh3]4 leads to quantitative removal of the Alloc group without any allyl back alkylation. Other scavengers such as morpholine or PhSiH3 are clearly inferior. Furthermore, this study has highlighted differences in the reaction kinetics of the deprotection step between secondary and primary amines such as those from α-amino acids.
科研通智能强力驱动
Strongly Powered by AbleSci AI