医学
急性呼吸窘迫综合征
机械通风
发病机制
低氧血症
弥漫性肺泡损伤
重症监护医学
肺
肺水肿
人口
入射(几何)
内科学
病理
急性呼吸窘迫
物理
光学
环境卫生
作者
Elizabeth Johnson,Michael A. Matthay
出处
期刊:Journal of Aerosol Medicine and Pulmonary Drug Delivery
[Mary Ann Liebert]
日期:2010-08-01
卷期号:23 (4): 243-252
被引量:593
标识
DOI:10.1089/jamp.2009.0775
摘要
Acute lung injury (ALI) remains a significant source of morbidity and mortality in the critically ill patient population. Defined by a constellation of clinical criteria (acute onset of bilateral pulmonary infiltrates with hypoxemia without evidence of hydrostatic pulmonary edema), ALI has a high incidence (200,000 per year in the US) and overall mortality remains high. Pathogenesis of ALI is explained by injury to both the vascular endothelium and alveolar epithelium. Recent advances in the understanding of pathophysiology have identified several biologic markers that are associated with worse clinical outcomes. Phase III clinical trials by the NHLBI ARDS Network have resulted in improvement in survival and a reduction in the duration of mechanical ventilation with a lung-protective ventilation strategy and fluid conservative protocol. Potential areas of future treatments include nutritional strategies, statin therapy, and mesenchymal stem cells.
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