免疫疗法
生物
淋巴因子激活杀伤细胞
癌症免疫疗法
免疫学
免疫系统
细胞
体外
自然杀伤细胞
干细胞
细胞疗法
造血
癌症研究
细胞生物学
白细胞介素21
T细胞
细胞毒性T细胞
生物化学
遗传学
作者
Martha Luevano,Alejandro Madrigal,Aurore Saudemont
摘要
Natural killer (NK) cells are part of the innate immune system and are an alluring option for immunotherapy due to their ability to kill infected cells or cancer cells without prior sensitization. Throughout the past 20 years, different groups have been able to reproduce NK cell development in vitro, and NK cell ontogeny studies have provided the basis for the establishment of protocols to produce NK cells in vitro for immunotherapy. Here, we briefly discuss NK cell development and NK cell immunotherapy approaches. We review the factors needed for NK cell differentiation in vitro, which stem cell sources have been used, published protocols, challenges and future directions for Good Manufacturing Practice protocols.
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