Novel Therapeutic Strategies for Chagas` Disease

Chagas and ends with the publication of "Manual of Tropical and Infectious Diseases" in 1935, at which point no major advances in the discovery of trypanocidal drugs had been made. In the second phase, between 1936 and 1960, numerous substances were empirically tested for the treatment of the disease, generating controversial results. The third phase, which started in 1961, was characterized by studies that clearly demonstrated the effectiveness of some compounds, e.g. nitrofurazone (1) (Figure The clinical trials showed that nitrofurazone (1) might be effective in the therapy for the disease but most patients were unable to tolerate the side effects at the doses and the time required for healing. However, the discovery of nitrofurazone (1) began a new era in the therapy of Chagas' disease