Cyclic Peptides via Ligation Methods

In this chapter, we describe how ligation methods have facilitated synthetic access to a range of head-to-tail cyclic peptides found in nature. We focus on peptides that have been the subject of studies in our laboratory, including orbitides, paws-derived peptides, conotoxins, θ-defensins, and cyclotides. Such peptides are of interest for therapeutic applications because they are typically very stable and resistant to proteases.