生物相容性
介孔二氧化硅
药物输送
纳米技术
壳聚糖
纳米颗粒
多糖
表面改性
材料科学
毒品携带者
介孔材料
化学
化学工程
有机化学
催化作用
物理化学
工程类
作者
Ying Kuang,Junjun Zhai,Qinjian Xiao,S. Zhao,Cao Li
标识
DOI:10.1016/j.ijbiomac.2021.10.142
摘要
Mesoporous silica nanoparticles (MSNs) have been well-researched in the design and fabrication of advanced drug delivery systems (DDSs) due to their advantages such as good biocompatibility, large specific surface area and pore volume for drug loading, easily surface modification, adjusted size and good thermal/chemical stability. For MSN-based DDSs, gate materials are also necessary. And natural polysaccharides, one kind of the most abundant natural resource, have been widely applied as the "gatekeepers" in MSN-based DDSs. Polysaccharides are cheap and rich in sources with good biocompatibility, and some of them have important biological functions. In this review article, polysaccharides including chitosan, hyaluronic acid, sodium alginate and dextran, et al. are briefly introduced. And the preparation processes and properties such as controlled drug release, cancer targeting and disease diagnosis of functional polysaccharide/MSN-based DDSs are discussed.
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