老化
皮肤病科
医学
衰老
皮肤老化
表型
药品
生物
药理学
内科学
遗传学
基因
作者
J.H. Park,Jung Eun Yoon,Y.H. Kim,T.J. Park,Hee Young Kang
摘要
Senescent cells accumulate in several tissues during ageing, including the skin, and contribute to the functional decline of the skin via the senescence-associated secretory phenotypes (SASPs) 1 . Due to the potential negative effects of SASPs during the ageing process, drugs that selectively target senescent cells or SASPs represent an important therapeutic strategy to delay skin ageing. The selective induction of cell death specifically to kill senescent cells using drugs, referred to as senolytics, is a main approach to achieve this strategy 2 .
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