利培酮
精神分裂症(面向对象编程)
谷胱甘肽过氧化物酶
过氧化氢酶
内科学
医学
精神病理学
超氧化物歧化酶
抗氧化剂
心理学
精神科
内分泌学
作者
Haixia Liu,Hua Liu,Shuling Jiang,Lei Su,Yi Lu,Zhenli Chen,Xiaojing Li,Xirong Li,Xuemei Wang,Meihong Xiu,Xiang Yang Zhang
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2021-11-11
卷期号:20 (9): 1793-1803
标识
DOI:10.2174/1570159x19666211111123918
摘要
There are various differences in the response to different antipsychotics and antioxidant defense system (ADS) by sex. Previous studies have shown that several ADS enzymes are closely related to the treatment response of patients with antipsychotics-naïve first-episode (ANFE) schizophrenia. Therefore, the main goal of this study was to assess the sex difference in the relationship between changes in ADS enzyme activities and risperidone response. The plasma activities of glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD) and total antioxidant status (TAS) were measured in 218 patients and 152 healthy controls. Patients were treated with risperidone for 3 months, and we measured PANSS for psychopathological symptoms and ADS biomarkers at baseline and at the end of 3 months of treatment. We compared sex-specific group differences between 50 non-responders and 168 responders at baseline and at the end of the three months of treatment. We found that female patients responded better to risperidone treatment than male patients. At baseline and 3-month follow-up, there were no significant sex differences in TAS levels and three ADS enzyme activities. Interestingly, only in female patients, after 12 weeks of risperidone treatment, the GPx activity of responders was higher than that of non-responders. These results indicate that after treatment with risperidone, changes in GPx activity were associated with treatment response, suggesting that changes in GPx may be a predictor of response to risperidone treatment in female patients with ANFE schizophrenia.
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