猪链球菌
脑膜炎
血清型
病死率
微生物学
医学
多位点序列分型
肺炎链球菌
感染性休克
流行病学
生物
病毒学
免疫学
儿科
内科学
基因型
毒力
败血症
抗生素
基因
生物化学
作者
Ni Made Susilawathi,Ni Made Adi Tarini,Ni Nengah Dwi Fatmawati,I Putu Bayu Mayura,Anak Agung Ayu Suryapraba,I Made Subrata,Anak Agung Raka Sudewi,Gusti Ngurah Mahardika
标识
DOI:10.3201/eid2512.181709
摘要
Streptococcus suis is an emerging agent of zoonotic bacterial meningitis in Asia. We describe the epidemiology of S. suis cases and clinical signs and microbiological findings in persons with meningitis in Bali, Indonesia, using patient data and bacterial cultures of cerebrospinal fluid collected during 2014-2017. We conducted microbiological assays using the fully automatic VITEK 2 COMPACT system. We amplified and sequenced gene fragments of glutamate dehydrogenase and recombination/repair protein and conducted PCR serotyping to confirm some serotypes. Of 71 cases, 44 were confirmed as S. suis; 29 isolates were serotype 2. The average patient age was 48.1 years, and 89% of patients were male. Seventy-seven percent of patients with confirmed cases recovered without complications; 11% recovered with septic shock, 7% with deafness, and 2% with deafness and arthritis. The case-fatality rate was 11%. Awareness of S. suis infection risk must be increased in health promotion activities in Bali.
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