Pharmacokinetics of Florfenicol in Blood of the Culture Korean Rockfish Following Single Oral Administration

The pharmacokinetics characterization of florfenicol(FF) after single oral medication was studied in the cultured korean rockfish, Sebastes schlegelii, using high performance liquid chromatography(HPLC). After single oral medication of FF(20 ㎎/㎏ body weight) in the cultured Korean rockfish(590±50 g, 23±1.5℃), the FF concentration in the serum was determined at different period(1, 5, 10, 15, 24, 30, 50 and 168 h post dose). The pharmacokinetics profile of FF oral medication in serum were analyzed to a one- or two-compartment model by WinNonlin program, respectively. Under the one-compartment model, the area under the concentration-time curve(AUC), maximum concentration(Cmax) and time for maximum concentration(Tmax) were 31.84 ㎍·h/㎖, 1.14 ㎍/㎖, and 9.3 h, respectively. Under the two-compartment model, the AUC, Cmax and Tmax were 45.52 ㎍·h/㎖, 1.14 ㎍/㎖ and 9.43 h, respectively. The results of this study could be used for determining efficacy dosage and withdrawal times of FF for the therapy of bacterial diseases in korean rockfish.