类有机物
芯片上器官
干细胞
生物
计算生物学
神经科学
细胞生物学
纳米技术
微流控
材料科学
作者
Zhen Wang,Xingdao He,Haowen Qiao,Pu Chen
出处
期刊:Tissue Engineering Part A
[Mary Ann Liebert]
日期:2020-06-01
卷期号:26 (11-12): 656-671
被引量:35
标识
DOI:10.1089/ten.tea.2019.0251
摘要
Organoid and organ-on-a-chip have evolved as two critical but distinct approaches to develop human physiologically and pathologically relevant in vitro models. Although rapid progress has been witnessed in the past decade, there is no systematic comparison of their status and trends based on the scientometric analysis. In this study, we performed a comparative study of organoid and organ-on-a-chip using bibliometric methods. A total of 2790 documents published between 2009 and 2018 were retrieved and analyzed. Our results showed that both organoid and organ-on-a-chip had experienced rapid growth in their academic and social impacts and influenced a wide spectrum of disciplines, but with a major distinct focus on Cell Biology and Nanoscience Nanotechnology, respectively. The hotspots of organoid research were expanding from in vitro differentiation of Lgr5 stem cells to mechanistic studies of diseases, while the hotspots of the organ-on-a-chip research were transiting from the establishment of microfluidic devices for in vitro cell culture to stem cell differentiation and tissue engineering. Interestingly, there was a growing trend of combining organoid with organ-on-a-chip in the last few years. This comparative study presented a unique perspective to understand the evolutive history and future trends of organoid and organ-on-a-chip for emerging human relevant in vitro organotypic models. Organoid and organ-on-a-chip, which served as emerging human physiologically and pathologically relevant in vitro models, hold a great promise to revolutionize the conventional paradigm in basic and clinical research. The fields of organoid and organ-on-a-chip have advanced rapidly over the past decade while lacking comparative studies based on bibliometric methods. This article provided the first scientometric study of these two fields from the unique perspectives of their research hotspots, influencing scientific areas, and global trends. Our bibliometric work will provide a quantitative and timely summary of these two fields for the researchers in the tissue engineering field.
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