拉莫三嗪
癫痫
卡马西平
医学
钠通道
神经病理性疼痛
神经科学
普瑞巴林
钠通道阻滞剂
抗惊厥药
多发性硬化
药理学
麻醉
心理学
化学
精神科
钠
有机化学
作者
Massimo Mantegazza,Giulia Curia,Giuseppe Biagini,David S. Ragsdale,Massimo Avoli
标识
DOI:10.1016/s1474-4422(10)70059-4
摘要
Voltage-gated sodium channels (VGSCs) are key mediators of intrinsic neuronal and muscle excitability. Abnormal VGSC activity is central to the pathophysiology of epileptic seizures, and many of the most widely used antiepileptic drugs, including phenytoin, carbamazepine, and lamotrigine, are inhibitors of VGSC function. These antiepileptic drugs might also be efficacious in the treatment of other nervous system disorders, such as migraine, multiple sclerosis, neurodegenerative diseases, and neuropathic pain. In this Review, we summarise the structure and function of VGSCs and their involvement in the pathophysiology of several neurological disorders. We also describe the biophysical and molecular bases for the mechanisms of action of antiepileptic VGSC blockers and discuss the efficacy of these drugs in the treatment of epileptic and non-epileptic disorders. Overall, clinical and experimental data indicate that these drugs are efficacious for a range of diseases, and that the development of drugs with enhanced selectivity for specific VGSC isoforms might be an effective and novel approach for the treatment of several neurological diseases.
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