Ceftazidime Influencing Procalcitonin Production in Rats: A Preliminary Study of Its Mechanism

OBJECTIVE To test the effect of filtrates of Escherichia coli induced by various concentrations of ceftazidime on synthesis of procalcitonin(PCT) in rats. METHODS Sixty rats were divided into 6 groups and injected in tail-vein injection.Blood filtrates were collected and used to detect PCT,obtained from vein behind eyes after 16 h. RESULTS Filtrates obtained from E.coli cultures dealing with different concentration ceftazidime stimulated rats,the number of induced procalcitonin was increased following decline of antibiotic concentration.Strong negative correlation was found between procalcitonin and concentration of ceftazidime. CONCLUSIONS The lower concentration of ceftazidime induces more PCT and the higher concentration induces fewer PCT.