Animal Models of Chronic Obstructive Pulmonary Disease in Pharmacological Research

The animal models of chronic obstructive pulmonary disease were reviewed and analyzed.It is hoped to provide a new train of chronic obstructive pulmonary disease(COPD) therapeutic drug development.Data on COPD and animal models in recent years were searched by the CAS Shanghai institute of materia database platform.The advantages and disadvantages of several animals as a COPD animal model were summarized,and the methods for COPD model and the relevant indicators to judge the successfulness of COPD model were established.Because of the complex pathogenesis of the COPD,it was failed to approach a unified COPD modeling standard.The article reported that several method unions are mostly used.This review hopes to provide some reference for the new treatments for COPD drug development.We expect to establish a standardized model of COPD for the disease treatment and research in the future