The application of CT perfusion imaging and CT angiography in early ischemic stroke

Objective To investigate the effect of computed tomography perfusion (CTP)imaging and computed tomography angiography (CTA)in detecting ischemic penumbra and location of early ischemic stroke. Methods 20 patients of acute ischemic stroke were reviewed. CTP were applied for all of them and CTA were added in 8 cases within 24 hour after onset. Cerebral blood flow and cerebral blood volume were measured, the mean transmit time(MTT)and cerebrovascular image were analyzed. Results CBF and CBV were decreased as well as MTT were delayed in the ischemic center and ischemic penumbra in 16 cases of acute cerebral infarction and 4 cases of TIA,compared to normal side of brain. Ischemic penumbra were found in 15 cases. With CTA,occlusion of local vessels was confirmed in the same area as CTP showed in 8 of 15 cases. Conclusion CTP imaging can accurately and clearly to show the location and range of ischemic penumbra,together with CTA,can play an important part in diagnosis of acute ischemic stroke and guide the selection of local intra-arterial thrombolytic therapy.