Research progress of the dual effects of PTH on bone metabolism

[Summary] The delicate balance between bone formation by osteoblasts and bone resorption by osteoclasts plays a key role in bone remodeling.PTH is one of the important hormones which regulate calcium and phosphate homeostasis.PTH has dual effects on bone metabolism: continuous administration of PTH causes bone resorption,intermittent administration induces bone formation,but the mechanism is unclear.It will be the research focus to identify the mechanism,and this will be helpful to use the anabolic actions of PTH for osteoporosis treatment.In future,using the dual effects of PTH on bone metabolism may be a novel therapy for bone malformation.