Protective Function of KD on Myocardial Ischemia-reperfusion Injury in Rabbit

[Objective]To discuss the effect of Ketogenic diet(KD) on myocardial ischemia-reperfusion injury in rabbit.[Methods]After pretreatment normal diet(ND) and KD respectively in male rabbits for 6 weeks,all the rabbits were ligated with the left anterior descending coronary arteries for 30 min and then recovered reperfusion for 180 min.The protection of KD on myocardial ischemia-reperfusion injury was evaluated by monitoring of ECG and serum creatine kinases,and myocardial infarct size measurements.[Results]In Group A(ND+ sham operation) LDH,CK is not elevated,without change in ECG and myocardial infarction.In Group B(ND + ischemia-reperfusion),the changes were significant.The injury of Group C(KD + ischemia-reperfusion) was lighter than that of Group B.[Conclusion]KD intervention relives the ischemia-reperfusion injury.