Correlation between degree of obesity and insulin resistance in patients with nonalcoholic fatty liver disease

Objective To investigate the correlation between degree of obesity and insulin resistance(IR) in patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 168 patients with NAFLD were enrolled and 32 healthy subjects were served as controls spontaneously.Body height,weight,fasting blood-glucose(FPG) and fasting insulin(FINS) were recorded and body mass index(BMI) and homeostasis model assessment of insulin resistance index(HOMA-IRI) were calculated.Results Levels of BMI,FPG,FINS,HOMA-IRI in patients with NAFLD were all elevated as compared with the controls(all P 0.05).Meanwhile,with the progressive development of obesity,the IR was gradually enhanced(all P 0.05).Conclusions Hyperinsulinemia and IR may occurred in patients with NAFLD.Moreover,Obesity can aggravate IR and induce secondary glycometabolic disorder.