The technique of ozonation and combined treatment in the area of wastewater treatment is widely applicated, such as, tanker wastewater, aniline wastewater, refinery wastewater, pesticide wastewater, textile wastewater, dyeing wastewater, coke plant wastewater, phenolic compounds wastewater, steroid hormones, low-concentration organic wastewater, pharmaceutical wastewater, petrochemical wastewater, photographic waste water, waste seepage filtrate, micro-polluted source water and drinking water and so on. There are some analysis and commentary to its application and research, and introduced the new progress of the technique of ozonation and combined treatment in recent years.