医学
疾病
血管平滑肌
心肌肥大
机制(生物学)
血管紧张素II
肌肉肥大
高血压的病理生理学
生物信息学
临床试验
平滑肌
内科学
心脏病学
血压
生物
哲学
认识论
出处
期刊:Current Opinion in Nephrology and Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:1993-03-01
卷期号:2 (2): 299-306
被引量:7
标识
DOI:10.1097/00041552-199303000-00018
摘要
The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It is clear that this peptide has direct growth effects on vascular smooth muscle cells and cardiocytes as well as indirect effects by stimulating the synthesis of growth factors or potentiating their effects. However, the details of its action need clarification. Abnormalities in endothelium-derived relaxing factor regulation are a new pathogenetic mechanism of hypertension and are also likely to be intimately involved in the development of hypertensive cardiovascular disease. In the clinical arena, converting enzyme inhibitors are emerging as the best antihypertensive agents, and new therapeutic trials add further support to the suspicion that, when in doubt, it is better to treat.
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