Proteomics: A new dimension to decode small cell lung cancer

Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and illustrate the potential of this knowledge to identify new SCLC vulnerabilities. Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and illustrate the potential of this knowledge to identify new SCLC vulnerabilities. Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategiesLiu et al.CellJanuary 04, 2024In BriefComprehensive proteogenomic characterization of small cell lung cancer using paired tumor and normal adjacent tissues provides insights into tumorigenesis, potential prognostic biomarkers, and immune landscape; identifies therapeutic strategies for four subtypes; and creates a resource for further research. Full-Text PDF