骨整合
钛
表面改性
对偶(语法数字)
金属
化学
水溶液中的金属离子
纳米技术
材料科学
冶金
医学
植入
外科
艺术
文学类
物理化学
作者
Jingyang Kang,Sikun Meng,Chenhui Liu,Huachun Wang,Tianzhen Zhang,Qi Cheng,Mei Li
标识
DOI:10.1016/j.colsurfb.2025.114717
摘要
Titanium (Ti) implants are widely used for tooth replacement due to their exceptional mechanical properties and high biocompatibility. However, their inherently inert surface limits osteogenic potential and makes them prone to bacterial colonization, increasing the risk of biofilm formation and implant-related infections. To address these limitations, surface modification of Ti is essential. This study aimed to enhance the surface properties of Ti by coating it with polydopamine (PDA) and further doping it with copper and calcium ions. TPDA was prepared and subsequently used to fabricate TPDA@Cu and TPDA@CuCa samples. Material characterization confirmed that TPDA@CuCa exhibited excellent surface wettability and biocompatibility, with Cu 2 + and Ca 2+ being continuously and stably released in liquid environments. Additionally, TPDA@CuCa significantly improved protein adsorption, facilitating favorable cellular interactions. In vitro experiments demonstrated that TPDA@CuCa exhibited strong antimicrobial activity against Escherichia coli and Staphylococcus aureus, enhanced osteoblast adhesion, mineralization, and upregulated osteogenic gene expression. This bifunctional surface modification strategy offers a promising approach to enhancing both the osteogenic and antibacterial properties of Ti implants. • Polydopamine coating enables Cu 2+ and Ca 2+ incorporation on titanium surfaces. • TPDA@CuCa promotes protein adsorption and enhances osteoblast adhesion and differentiation. • Cu 2+ and Ca 2+ release from TPDA@CuCa supports sustained bone mineralization. • TPDA@CuCa exhibits strong antibacterial activity against E. coli and S. aureus . • This dual-functional coating strategy enhances both antibacterial and osteogenic properties.
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