医学
糖尿病肾病
危险系数
内科学
糖尿病
累积发病率
比例危险模型
肾功能
2型糖尿病
蛋白尿
队列
肌酐
队列研究
置信区间
内分泌学
胃肠病学
作者
Zhiyuan Wu,Siqi Yu,Qian Zhu,Zhiwei Li,Haiping Zhang,Xiaoping Kang,Zongkai Xu,Xinlei Miao,Xiangtong Liu,Xia Li,Jingbo Zhang,Wei Wang,Lixin Tao,Xiuhua Guo
标识
DOI:10.1016/j.diabres.2022.110079
摘要
To evaluate the longitudinal association of remnant cholesterol with the incidence of diabetic nephropathy using a Chinese diabetes cohort.We included 4237 individuals with type 2 diabetes during 2013-2014 from Beijing Health Management Cohort. Remnant cholesterol was defined by Martin-Hopkins equation. Diabetic nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate. We calculated the hazard ratio (HR) and 95% confidence interval (CI) for incident diabetic nephropathy using adjusted Cox proportional hazards regression.The median [IQR] age was 55 [48, 64] years, and 3 256 (76.8 %) were men. During follow-up, 248 (5.9 %) participants developed diabetic nephropathy. One-SD increase of baseline and average cumulative remnant cholesterol were significantly associated with an increased risk of diabetic nephropathy, and the adjusted HRs were 1.208 (95 % CI: 1.098-1.329) and 1.216 (95 % CI: 1.102-1.341), respectively. Individuals in the highest tertile of baseline and average cumulative remnant cholesterol had a 82.3 % and 87.6 % excess risk of diabetic nephropathy, compared with those in the lowest.Remnant cholesterol is independently associated with incident diabetic nephropathy in type 2 diabetes.
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