新生内膜
医学
新生内膜增生
PDZ域
血管平滑肌
相扑蛋白
癌症研究
细胞生物学
增生
细胞
细胞生长
表型
下调和上调
血管壁
内膜增生
再狭窄
发病机制
表型转换
核蛋白
作者
Hanyan Yang,Yuchun Zhong,Wenjie Guo,Wenjing Guo,Boliang Chen,Zhiming Lin,Qin Zhang,Rongjun Zou,Xiaolong Cao,Fengxian Li,Wei Feng,Jianyun Yan,Zhi Zeng,Wei Wang,Kunfu Ouyang,Xinjie Xu,Xiaoping Fan,Xi Fang,Shanshan Ai,Canzhao Liu
出处
期刊：Circulation
[Lippincott Williams & Wilkins]
日期：2025-09-16
卷期号：152 (15): 1087-1108
被引量：2
标识
DOI：10.1161/circulationaha.124.072525
摘要
These results demonstrate that SUMOylation of TAX1BP3 at K116 enables its nucleocytoplasmic shuttling during phenotypic switching of VSMCs. TAX1BP3 competitively interacts with the YAP-TEAD complex in a noncanonical PDZ manner and exerts its protective role in vascular neointimal hyperplasia primarily through the regulation of cell proliferation.
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(2025-6-4)
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