阿波贝克
生物
胰腺癌
癌症研究
突变
免疫检查点
肿瘤微环境
转录组
癌症
细胞周期
突变
遗传学
免疫疗法
基因
基因表达
基因组
作者
Xiaozhou Yu,Gang Shen,Ziyun Liu,Parhat Kaysar,Xiaobin Shang,Bo Ni,Weihao Zhang,Yaoyao Zhou,Yongjie Xie,Weishuai Liu
出处
期刊:Genomics
[Elsevier BV]
日期:2025-08-12
卷期号:117 (5): 111098-111098
标识
DOI:10.1016/j.ygeno.2025.111098
摘要
Our study illustrated the characterization of APOBEC mutagenesis in multiple cancer types and highlighted its potential value as a prognostic and immunotherapeutic biomarker for PAAD, and finally demonstrated the effectiveness of irinotecan, an inhibitor of APMs, in vivo and in vitro experiments.
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