Asymmetric Gold-catalyzed Alkyne Transformations for Synthesis of Axial, Helical, and Planar Chirality

Gold-catalyzed asymmetric alkyne transformations have emerged as a powerful strategy for constructing chiral architectures due to gold's unique carbophilic π-acidity. This review comprehensively summarizes recent breakthroughs in constructing non-central chirality, focusing on axial, helical, and planar chiral scaffolds. Beyond that, innovative ligand design and the underlying structure-activity relationships that govern stereocontrol are highlighted in this review. This overview provides insights into current trends in gold-catalyzed asymmetric synthesis.