光遗传学
神经科学
神经保护
视蛋白
生物
视网膜
视紫红质
生物化学
作者
Edward H. Wood,Alexander Kreymerman,Tia J. Kowal,David Buickians,Yang Sun,Stephanie Muscat,Mark Mercola,Darius M. Moshfeghi,Jeffrey L. Goldberg
标识
DOI:10.1016/j.preteyeres.2022.101153
摘要
Optogenetics is defined as the combination of genetic and optical methods to induce or inhibit well-defined events in isolated cells, tissues, or animals. While optogenetics within ophthalmology has been primarily applied towards treating inherited retinal disease, there are a myriad of other applications that hold great promise for a variety of eye diseases including cellular regeneration, modulation of mitochondria and metabolism, regulation of intraocular pressure, and pain control. Supported by primary data from the authors’ work with in vitro and in vivo applications, we introduce a novel approach to metabolic regulation, Opsins to Restore Cellular ATP (ORCA). We review the fundamental constructs for ophthalmic optogenetics, present current therapeutic approaches and clinical trials, and discuss the future of subcellular and signaling pathway applications for neuroprotection and vision restoration.
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