钙
免疫疗法
癌症研究
化学
卟啉
光动力疗法
活性氧
佐剂
CD8型
生物物理学
免疫系统
免疫学
生物化学
医学
生物
有机化学
作者
Yun Yu,Bo‐Ru Xie,Xinhua Liu,Jing‐Jie Ye,Zhang Zhong,Xian‐Zheng Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-06-26
卷期号:17 (13): 12471-12482
被引量:8
标识
DOI:10.1021/acsnano.3c02126
摘要
Calcium ion therapy is a potential anticancer treatment. However, the cellular calcium-buffering mechanism limited the effectiveness of calcium ion therapy. Here, we constructed a mineralized porphyrin metal–organic framework (PCa) to produce calcium ions and reactive oxygen species (ROS), which destroyed cell calcium buffering capacity and amplified the cell damage caused by calcium overload. In addition, PCa could induce cell immunogenic death to release tumor-associated antigen (TAA) and be used as an adjuvant. Thus, PCa could increase DC maturation and promote the antitumor activity of CD8+ T cells. For mice experiment, PCa not only showed excellent tumor elimination on the subcutaneous breast tumor but also achieved obvious antimetastasis effect in the metastatic tumor model. This nanosystem could eliminate the primary tumor and boost effective antitumor immunotherapy for comprehensive anticancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI