心理学
焦虑
性二态性
认知
发展心理学
皮质酮
高架加迷宫
记忆力减退
备忘录
神经科学
激素
内科学
医学
精神科
作者
Ezequiel Batista do Nascimento,Aline Lima Dierschnabel,Ramón Hypolito Lima,Maria Bernadete C Sousa,Deborah Suchecki,Regina H. Silva,Alessandra Mussi Ribeiro
标识
DOI:10.1016/j.beproc.2022.104660
摘要
Stress encompasses reactions to stimuli that promote negative and positive effects on cognitive functions, such as learning and memory processes. Herein, we investigate the effect of restraint stress on learning, memory, anxiety levels and locomotor activity of male and female mice. We used the plus-maze discriminative avoidance task (PMDAT), a behavioral task based on the innate exploratory response of rodents to new environments. Moreover, this task is used to simultaneously evaluate learning, memory, anxiety-like behavior and locomotor activity. Male and female mice were tested after repeated daily restraint stress (4 h/day for 3 days). The results showed stress-induced deficits on aversive memory retrieval only in female mice, suggesting a sexual dimorphism on memory acquisition. Furthermore, stressed females exhibited increased anxiety-like behavior and decreased exploratory behavior. Plasma corticosterone levels were similarly increased by restraint stress in both sexes, suggesting that the behavioral outcome was not related to hormonal secretion. Our findings corroborate previous studies, showing a sexually dimorphic effect of restraint stress on cognition. In addition, our study suggests that stress-related acquisition deficit may be the consequence of elevated emotional response in females.
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