Long-acting HIV fusion inhibitor albuvirtide combined with ritonavir-boosted lopinavir for HIV-1-infected patients after failing the first-line antiretroviral therapy: 48-week randomized, controlled, phase 3 non-inferiority TALENT study

We read with great interest the article by Hou et al.1 which described that the HIV-1-related mortality is still high despite the scaling up of antiretroviral therapy (ART). The constant proportion of late-stage presentation among treatment-naïve people living with HIV (PLWH), especially severely immunosuppressed PLWH, is considered to be one of the reasons. We think there should also be some other challenges to reduce the mortality, to improve the treatment efficacy and to improve the life quality of patients.