四吡咯
代谢工程
合成生物学
代谢途径
乙酰丙酸
血红素
保健品
生化工程
生物合成
化学
生物化学
生物技术
生物
计算生物学
新陈代谢
酶
工程类
催化作用
作者
Jian Zhang,Zhiyong Cui,Yuan Zhu,Ziwei Zhu,Qingsheng Qi,Qian Wang
标识
DOI:10.1016/j.biotechadv.2021.107904
摘要
Tetrapyrroles are essential metabolic components produced by almost all organisms, and they participate in various fundamental biological processes. Tetrapyrroles are used as pharmaceuticals, food additives, and nutraceuticals, as well as in agricultural applications. However, their production is limited by their low extraction yields from natural resources and by the complex reaction steps involved in their chemical synthesis. Through advances in metabolic engineering and synthetic biology strategies, microbial cell factories were developed as an alternative method for tetrapyrrole production. Herein, we review recent developments in metabolic engineering and synthetic biology strategies that promote the microbial production of high-value compounds in the tetrapyrrole biosynthesis pathway (e.g., 5-aminolevulinic acid, heme, bilins, chlorophyll, and vitamin B12). Furthermore, outstanding challenges to the microbial production of tetrapyrrole compounds, as well as their possible solutions, are discussed.
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