| 标题 |
  Renal damage in primary aldosteronism: a systematic review and meta-analysis 原发性醛固酮增多症肾损害的系统评价和荟萃分析
相关领域
原发性醛固酮增多症
医学
肾功能
微量白蛋白尿
蛋白尿
醛固酮增多症
蛋白尿
泌尿科
内科学
醛固酮
肾
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| 网址 | |
| DOI | |
| 其它 | Results: Forty-six studies including 6056 patients with primary aldosteronism and 9733 patients affected by arterial hypertension without primary aldosteronism were included. After 8.5 years from hypertension diagnosis, patients with primary aldosteronism had an increased estimated glomerular filtration rate (eGFR) compared with hypertensive patients without primary aldosteronism [by 3.37 ml/min IQR (0.82-5.93)] and a more severe albuminuria [standard mean difference 0.55 (0.19-0.91)], resulting into an association with microalbuminuria [odds ratio (OR) 2.09 (1.40; 3.12)] and proteinuria [OR 2.68 (1.89;3.79)]. Following primary aldosteronism treatment, after a median follow-up of 12 months, a reduction in eGFR was observed [by -10.69 ml/min (-13.23; -8.16)], consistent in both medically and surgically treated patients. Similarly, a reduction in albumin excretion and an increase in serum creatinine were observed after treatment. |
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