| 标题 |
[高分]
 Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-68oo, a poly(ADP- ribose) polymerase inhibitor |
| 网址 | |
| DOI |
10.1158/1535-7163.MCT-02-0234
doi
|
| 其它 |
作者：Miknyoczki SJ, et al. 期刊：Molecular Cancer Therapeutics 发表时间：2003 Apr;2(4):371-382 PMID：12700281 Abstract Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that isimplicated in the repair of DNA damage. inhibition of PARP-1 through genetic knockouts causes cellsto become hypersensitive to various chemotherapeutic agents. We tested the chemopotentiatingability of the PARP-1 inhibitor, CEP-6800, when used in combination with temozolomide (TMZ),irinotecan (camptothecin or SN38), and cisplatin against U251MG glioblastoma, HT29 coloncarcinoma, and Calu-6 non-small cell lung carcinoma xenografts and cell lines, respectively. Exposureof tumor cells to TMZ, camptothecin (or SN38), and cisplatin before, or in the presence of, CEP-6800significantly increased the onset and the maqnitude of DNA damage, the duration for cells to effectrepair, and the onset, duration, or fraction of cells arrested at the G(2)/M boundary. |
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