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Fibroblast activation protein ligands for targeted delivery applications
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Assignee: Philochem AG Inventors: Biancofiore, Ilaria; Cazzamalli, Samuele; Dakhel Plaza, Sheila; Donckele, Etienne J.; Millul, Jacopo; Samain, Florent; Schmidt, Eleonore The present invention relates to ligands of Fibroblast Activation Protein (FAP), e.g. I, for the active delivery of various payloads (e.g. cytotoxic drugs, radionuclides, fluorophores, proteins and immunomodulators) at the site of disease. In particular, the present invention relates to the development of FAP ligands for targeting applications, in particular diagnostic methods and/or methods for therapy or surgery in relation to a disease or disorder, such as cancer, inflammation or another disease characterized by over-expression of FAP. |
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(2025-6-4)
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