| 标题 |
 Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism 相关领域
便秘
肠道菌群
医学
胃肠病学
不利影响
生理学
内科学
免疫学
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| 网址 | |
| DOI | |
| 其它 |
期刊：ACS Nano 作者：Mingzheng Wang; Ruitao Cha; Wenshuai Hao; Ran Du; Pai Zhang; et al 出版日期：2022-09-21 Constipation can seriously affect the quality of life and increase the risk of colorectal cancer. The present strategies for constipation therapy have adverse effects, such as causing irreversible intestinal damage and affecting the absorption of nutrients. Nanocrystalline cellulose (NCC), which is from natural plants, has good biocompatibility and high safety. Herein, we used NCC to treat constipation assessed by the black stool, intestinal tissue sections, and serum biomarkers. We studied the effect of NCC on gut microbiota and discussed the correlation of gut microbiota and metabolites. We evaluated the long-term biosafety of NCC. NCC could effectively treat constipation through gut microbiota metabolism, which required a small dosage and did not affect the organs and intestines. NCC could be used as an alternative to medications and dietary fiber for constipation therapy. |
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