| 标题 |
 Metal-free organocatalytic S-formylation of thiols using CO2 相关领域
甲酰化
化学
有机催化
组合化学
有机化学
催化作用
对映选择合成
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| 网址 | |
| DOI | |
| 其它 |
S-formylation of thiols is achieved via an enzymatic process catalysed by formate dehydrogenase enzyme that fixes CO2 onto substrates, which plays a crucial role in regulating important biological pathways in living organisms. The achievement of this reactivity through a chemical approach could also be advantageous, which would allow the fixation of CO2 on a diverse range of thiols. Here we demonstrate a chemical process to prepare S-formyl thiols from CO2 using a mesoionic N-heterocyclic olefin under metal-free conditions. This catalytic reaction is used to diversify a variety of biologically active thiols obtained from natural terpenoids, fatty alcohols, antioxidants, and commercially accessible analgesic and anti-inflammatory medication molecules, as well as preparation of 13C-labelled formyl |
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(2025-6-4)
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