生物
子宫内膜
上皮-间质转换
细胞生物学
炎症体
胚胎
免疫系统
受体
雌激素
上皮
炎症
蜕膜化
内分泌学
间充质干细胞
男科
内科学
间质细胞
子宫
作者
Xi Cheng,Yu Zhang,Jinzhao Ma,Shuxian Wang,Rujun Ma,Xie Ge,Wei Zhao,Tongmin Xue,Li Chen,Bing Yao
出处
期刊:Molecular human reproduction
[Oxford University Press]
日期:2021-11-02
卷期号:27 (11)
被引量:3
标识
DOI:10.1093/molehr/gaab056
摘要
Endometrial receptivity is crucial for successful embryo implantation. It is regulated by multiple factors which include ovarian steroid hormones and the immune microenvironment among others. Nod-Like Receptor Pyrins-3 (NLRP3) is a key intracellular pattern-recognition receptor and a critical component of the inflammasome, which plays an essential role in the development of inflammation and of immune responses. However, the physiological functions of NLRP3 in the endometrium remain largely unclear. This study investigated the physiological and pathological significance of NLRP3 in human endometrial epithelial cell during the implantation window. NLRP3 is highly expressed during the mid-proliferative and mid-secretory phases of the human endometrium and transcriptionally up-regulated by estradiol (E2) through estrogen receptor β (ERβ). In addition, NLRP3 promotes embryo implantation and enhances epithelial-mesenchymal transition (EMT) of Ishikawa (IK) cells via both inflammasome-dependent and inflammasome-independent pathways, which might provide a novel insight into endometrial receptivity and embryo implantation. Our findings suggest that NLRP3, which is transcriptionally regulated by E2, induces epithelial-mesenchymal transition of endometrial epithelial cells and promotes embryo adhesion.
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