自愈水凝胶
光热治疗
材料科学
伤口愈合
适应性
生物医学工程
生物相容性
纳米技术
高分子化学
外科
冶金
医学
生态学
生物
作者
Libo Feng,Qin Chen,Huitong Cheng,Qiao Yu,Weifeng Zhao,Changsheng Zhao
标识
DOI:10.1002/adhm.202201049
摘要
Incomplete contact between a pre-formed hydrogel and irregular wound limits the therapeutic effect of the dressing and increases the risk of infection; while great concerns have remained regarding the potential toxicity of the residual additives of chemical crosslinking for in situ forming hydrogels. Therefore, it is desirable to develop a self-adaptive hydrogel in response to skin temperature with shape adaptability and efficient antibacterial properties to prevent microbial invasion. Herein, a dually-thermoresponsive hydrogel composed of poly(N-isopropylacrylamide) (PNIPAm) and methacrylated κ-carrageenan (MA-κ-CA) is designed with compliance at physiological temperature to realize shape adaptability for completely covering irregular wounds. Furthermore, the hydrogel with near-infrared (NIR)-responsive polypyrrole-polydopamine nanoparticles (PPy-PDA NPs) and Zn2+ -derived zeolitic imidazolate framework (ZIF-8) can generate localized heat and gradually release Zn2+ to realize safe, effective synergetic photothermal-chemical bactericidal capability. In addition, the release rate of Zn2+ can be accelerated by NIR-induced heating, and thus a more efficient sterilization can be provided to severely infected wounds. Therefore, the proposed hydrogel would serve as a promising wound dressing for the full course of wound healing, with the abilities of perfectly covering the wound and adapting to regenerating tissue, and controllable photothermal-chemical antibacterial capability to reach high bactericidal efficiency and long-term release of antibacterial agents.
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