胸腺细胞
CD8型
生物
细胞毒性T细胞
细胞生物学
谱系(遗传)
转录因子
T细胞
T细胞受体
双重否定
细胞分化
免疫学
遗传学
免疫系统
基因
体外
作者
Hirokazu Tanaka,Ichiro Taniuchi
出处
期刊:Current Topics in Microbiology and Immunology
日期:2013-01-01
被引量:2
摘要
CD4(+) helper and CD8(+) cytotoxic T cells, two major subsets of αβTCR expressing lymphocytes, are differentiated from common precursor CD4(+)CD8(+) double-positive (DP) thymocytes. Bifurcation of the CD4(+)/CD8(+) lineages in the thymus is a multilayered process and is thought to culminate in a loss of developmental plasticity between these functional subsets. Advances in the last decade have deepened our understanding of the transcription control mechanisms governing CD4 versus CD8 lineage commitment. Reciprocal expression and antagonistic interplay between two transcription factors, ThPOK and Runx3, is crucial for driving thymocyte decisions between these two cell fates. Here, we first focus on the regulation of ThPOK expression and its role in directing helper T cell development. We then discuss a novel aspect of the ThPOK/Runx3 axis in modifying CD4(+) T cell function upon exposure to gut microenvironment.
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