介孔二氧化硅
纳米技术
药物输送
纳米医学
生物相容性
纳米颗粒
生物利用度
材料科学
药品
医学
药理学
介孔材料
化学
生物化学
催化作用
冶金
作者
Flávia S.C. Rodrigues,António Campos,João Martins,António Francisco Ambrósio,Elisa J. Campos
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2020-12-02
卷期号:6 (12): 6587-6597
被引量:32
标识
DOI:10.1021/acsbiomaterials.0c01347
摘要
Vision is the most dominant of our senses, and it is crucial in every stage of our lives. Ocular diseases, regardless of whether they cause vision impairment or not, lead to personal and financial hardships. The anatomy and physiology of the eye strongly limit the efficacy of current ocular drug delivery strategies. Nanotechnology has been the ground for the development of powerful strategies in several fields, namely in medicine. This review highlights emerging nanotechnology-based solutions for improving ocular drug delivery and thus the bioavailability and efficacy of drugs. We focus our review on ambitious but promising approaches currently emerging to leverage the efficacy of nanoparticle-based systems in ocular therapy: (i) light-responsive nanoparticles, which enable spatiotemporal control of drug release; (ii) mesoporous silica nanoparticles, which offer high surface area-to-volume ratio, simple surface modification, good biocompatibility, and improved bioavailability; and (iii) contact lenses, which serve as a compliant method of nanoparticles use and as drug delivery systems for the treatment of ocular diseases.
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