Flow-dependent vasodilation of brachial artery in essential hypertension

Brachial artery hemodynamics including brachial artery diameter (D) and local blood flow velocity (V) was studied in 15 normotensive subjects (NT) and 19 age-matched hypertensive patients (HT) at rest using a bidimensional pulsed Doppler system during a 2-min period of distal circulatory occlusion and during reactive hyperemia. Kinetics of changes in V and D were determined during successive and reproducible maneuvers. V and D decreased significantly during distal circulatory occlusion in both groups. During reactive hyperemia, V reached similar maximum values in both groups, and D increased significantly in NT and HT. Changes in D during reactive hyperemia were positively and significantly correlated with changes in V recorded at the same level. No significant difference was found between the two groups. These results demonstrate noninvasively that there are velocity-dependent variations in the diameter of a large artery in humans and suggest that velocity-dependent vasodilation of the brachial artery is not impaired in essential hypertension.