介孔二氧化硅
纳米复合材料
脱发
纳米颗粒
材料科学
壳聚糖
毛囊
锌
铜
化学
纳米技术
药理学
介孔材料
医学
内科学
生物化学
有机化学
皮肤病科
催化作用
作者
Zhaowenbin Zhang,Wenbo Li,Di Chang,Zhongqing Wei,Endian Wang,Jing Yu,Yuze Xu,Yumei Que,Yanxin Chen,Chen Fan,Bing Ma,Yanling Zhou,Zhiguang Huan,Chen Yang,Feng Guo,Jiang Chang
标识
DOI:10.1016/j.bioactmat.2022.12.007
摘要
A nanocomposite microneedle (ZCQ/MN) patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin (ZCQ) was developed as a combination therapy for androgenic alopecia (AGA). The degradable microneedle gradually dissolves after penetration into the skin and releases the ZCQ nanoparticles. ZCQ nanoparticles release quercetin (Qu), copper (Cu2+) and zinc ions (Zn2+) subcutaneously to synergistically promote hair follicle regeneration. The mechanism of promoting hair follicle regeneration mainly includes the regulation of the main pathophysiological phenomena of AGA such as inhibition of dihydrotestosterone, inhibition of inflammation, promotion of angiogenesis and activation of hair follicle stem cells by the combination of Cu2+ and Zn2+ ions and Qu. This study demonstrates that the systematic intervention targeting different pathophysiological links of AGA by the combination of organic drug and bioactive metal ions is an effective treatment strategy for hair loss, which provides a theoretical basis for development of biomaterial based anti-hair loss therapy.
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