脱颗粒
免疫球蛋白E
机制(生物学)
翻译(生物学)
G蛋白偶联受体
受体
计算生物学
抗体
医学
免疫学
神经科学
心理学
生物
基因
生物化学
内科学
认识论
信使核糖核酸
哲学
作者
Vito Sabato,Didier G. Ebo,Marie‐Line M. van der Poorten,Alessandro Toscano,Athina L. Van Gasse,Christel Mertens,Michel van Houdt,Michiel Beyens,Jessy Elst
标识
DOI:10.1016/j.jaip.2022.12.014
摘要
Since the seminal description implicating occupation of the Mas-related G protein-coupled receptor X2 (MRGPRX2) in mast cell (MC) degranulation by drugs, many investigations have been undertaken into this potential new endotype of immediate drug hypersensitivity reaction. However, current evidence for this mechanism predominantly comes from (mutant) animal models or in vitro studies, and irrefutable clinical evidence in humans is still missing. Moreover, translation of these preclinical findings into clinical relevance in humans is difficult and should be critically interpreted. Starting from our clinical priorities and experience with flow-assisted functional analyses of basophils and cultured human MCs, the objectives of this rostrum are to identify some of these difficulties, emphasize the obstacles that might hamper translation from preclinical observations into the clinics, and highlight differences between IgE- and MRPGRX2-mediated reactions. Inevitably, as with any subject still beset by many questions, alternative interpretations, hypotheses, or explanations expressed here may not find universal acceptance. Nevertheless, we believe that for the time being, many questions remain unanswered. Finally, a theoretical mechanistic algorithm is proposed that might advance discrimination between MC degranulation from MRGPRX2 activation and cross-linking of membrane-bound drug-reactive IgE antibodies.
科研通智能强力驱动
Strongly Powered by AbleSci AI