Polyphenols of Ferula lehmanni Boiss. attenuate high-fat diet-induced liver injury by regulating lipid synthesis and remodeling the gut microbiota

, FLBP attenuated hepatic steatosis by regulating lipogenic factors and energy metabolism, reducing oxidative stress and enhancing antioxidants. Gut microbiota analysis showed that FLBP restored gut microbial diversity, enriched beneficial bacteria abundance and promoted short-chain fatty acid (SCFA) production. Antibiotic-induced microbiota ablation abolished the hepatoprotective effects of FLBP, confirming the essential role of the gut microbiota. Collectively, our findings demonstrate that FLBP alleviates HFD-induced liver injury by regulating hepatic lipid synthesis and remodeling the gut microbiome, highlighting its potential as a dietary intervention for managing diet-related liver diseases.