一氧化二氮
抗抑郁药
安慰剂
脑电图
麻醉
萧条(经济学)
评定量表
重性抑郁障碍
大脑活动与冥想
心理学
难治性抑郁症
医学
神经科学
认知
发展心理学
替代医学
病理
经济
宏观经济学
海马体
作者
Xuexiao Shao,Danfeng Yan,Wenwen Kong,Shuting Sun,Mei Liao,Wenwen Ou,Yan Zhang,Zheng Fang,Xiaowei Li,Lingjiang Li,Bin Hu
标识
DOI:10.1016/j.psychres.2023.115072
摘要
Nitrous oxide has rapid antidepressant effects in patients with treatment-resistant depression (TRD), but its underlying mechanisms of therapeutic actions are not well understood. Moreover, most of the current studies lack objective biological indicators to evaluate the changes of nitrous oxide-induced brain function for TRD. Therefore, this study assessed the effect of nitrous oxide on brain function for TRD based on event-related potential (ERP) components and functional connectivity networks (FCNs) methods. In this randomized, longitudinal, placebo-controlled trial, all TRD participants were divided into two groups to receive either a 1-hour inhalation of nitrous oxide or a placebo treatment, and they took part in the same task-state electroencephalogram (EEG) experiment before and after treatment. The experimental results showed that nitrous oxide improved depressive symptoms better than placebo in terms of 17-Hamilton Depression Rating Scale score (HAMD-17). Statistical analysis based on ERP components showed that nitrous oxide-induced significant differences in amplitude and latency of N1, P1, N2, P2. In addition, increased brain functional connectivity was found after nitrous oxide treatment. And the change of network metrics has a significant correlation with decreased depressive symptoms. These findings may suggest that nitrous oxide improves depression symptoms for TRD by modifying brain function.
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