Gender-specific association of adverse childhood experiences with frailty index level and trajectory in China

医学 虚弱指数 中国 联想(心理学) 索引(排版) 弹道 老年学 人口学 法学 计算机科学 政治学 万维网 天文 认识论 物理 哲学 社会学
作者
Qīng Wáng
出处
期刊:Maturitas [Elsevier BV]
卷期号:170: 1-8 被引量:3
标识
DOI:10.1016/j.maturitas.2023.01.011
摘要

The determinants of gender differences in frailty remain unknown but may include social factors. International attention is increasingly focusing on the adverse childhood experiences of women. This study therefore examined the gender-specific association of adverse childhood experiences with frailty index level and trajectory.This population-based study used data from the China Health and Retirement Longitudinal Study, with a nationally representative sample of people aged 45 years or more. The frailty index was based on 41 health measurements, and 18 types of adverse childhood experiences were examined. Weighted ordered logistic models were used with additive interaction.Compared with those exposed to one or no adverse events, exposure to two or three childhood adverse experiences was associated with a 44 % (95%CI: 1.16-1.80) increase in the likelihood of frail status for women, but not significantly associated with the likelihood of frail status for men. Additionally, for men and women, experiencing four or more adversities was associated with a 69 % (95%CI: 1.36-2.09) and a 138 % (95%CI: 1.93-2.94) increase in the likelihood of frail status, respectively. A similar association was found between accumulative scores for adverse childhood experiences and trajectory of the frailty index (men vs. women: OR of exposure to two or three adversities: 1.17 (95%CI: 0.84-1.64) vs. 1.26 (95%CI: 1.02-1.56); OR of exposure to four or more adversities: 1.70 (95%CI: 1.24-2.34) vs. 2.12 (95%CI: 1.70-2.63)). The greatest increase in risk of frailty was observed among men and women experiencing a high level of adversity, followed by socioeconomic deprivation and intrafamilial aggression. There was a significant additive interaction between women and childhood socioeconomic deprivation or a high level of adversity. The risk of being frail or having a rapidly increasing frailty index trajectory for women with a high level of adversity was approximately 4.34 (95%CI: 3.36-5.59) and 4·07 (95%CI: 3·34-4.96) times higher than that for men with a low level of adversity. However, gender differences were not found in the effects of childhood intrafamilial aggression.Men and women routinely experienced adult frailty as a result of adverse childhood events. The biological interaction between women and adverse childhood experiences was evident, with women's frailty being more sensitive to childhood socioeconomic deprivation and a high level of adversity. The findings have important implications for reducing the risk of frailty by mitigating early life stress, especially among women.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
rougelike完成签到,获得积分10
1秒前
1秒前
why关闭了why文献求助
1秒前
希望天下0贩的0应助cimy采纳,获得10
1秒前
科研通AI5应助gpa采纳,获得10
1秒前
Nico_Ding发布了新的文献求助10
1秒前
沉静念烟发布了新的文献求助10
2秒前
十三应助baobao采纳,获得10
2秒前
无忌发布了新的文献求助10
2秒前
无敌暴龙学神完成签到,获得积分10
3秒前
3秒前
东风完成签到,获得积分10
3秒前
晚风完成签到,获得积分10
3秒前
常常完成签到,获得积分10
3秒前
4秒前
Eman完成签到,获得积分10
4秒前
欣喜的香彤完成签到,获得积分10
4秒前
科研通AI5应助和花花采纳,获得10
4秒前
阿南发布了新的文献求助10
4秒前
iebdus123发布了新的文献求助10
5秒前
坚强的草履虫完成签到,获得积分10
5秒前
缥缈纲应助科研通管家采纳,获得10
6秒前
6秒前
机灵柚子应助科研通管家采纳,获得20
6秒前
打打应助esther816采纳,获得10
6秒前
科目三应助科研通管家采纳,获得30
6秒前
郭二发布了新的文献求助10
7秒前
7秒前
小二郎应助科研通管家采纳,获得10
7秒前
华仔应助科研通管家采纳,获得10
7秒前
FashionBoy应助科研通管家采纳,获得10
7秒前
乐乐应助科研通管家采纳,获得10
8秒前
FAFU发布了新的文献求助10
8秒前
CodeCraft应助科研通管家采纳,获得10
8秒前
科研通AI5应助li采纳,获得10
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
爆米花应助xzx采纳,获得10
8秒前
大个应助科研通管家采纳,获得10
8秒前
万能图书馆应助soso采纳,获得10
9秒前
机灵柚子应助科研通管家采纳,获得20
9秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Mobilization, center-periphery structures and nation-building 600
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3792984
求助须知:如何正确求助?哪些是违规求助? 3337735
关于积分的说明 10286331
捐赠科研通 3054258
什么是DOI,文献DOI怎么找? 1675917
邀请新用户注册赠送积分活动 803905
科研通“疑难数据库(出版商)”最低求助积分说明 761598