Chikungunya cases with vector-adaptive mutations detected in Italy imported from Madagascar

Highlight Two imported Chikungunya cases were detected in northern Italy in 2025, linked to the strains circulating in Réunion Island. Genomic analysis revealed mutations enhancing Aedes albopictus transmission. These findings raise concern for local spread and highlight the importance of genomic surveillance, vector control, and preparedness against emerging arboviral threats in Europe.