癌症研究
癌变
靶向治疗
癌症
肺癌
腺癌
癌基因
MAPK/ERK通路
体内
生物
医学
信号转导
肿瘤科
细胞周期
内科学
遗传学
作者
Ashley V. DiMarco,Mirunalini Ravichandran,Jeff Lau,Anthony Lima,Jennifer A. Lacap,Pablo Saenz-Lopez Larrocha,Eva Lin,Julie Weng,Luca Gerosa,Thomas Hunsaker,Yang Xiao,Monika Miś,Charles Havnar,Wennie Chen,Kai Barck,Klára Tótpál,Oded Foreman,Nicole M. Sodir,Mark Merchant,Danilo Maddalo
出处
期刊：Cancer Research
[American Association for Cancer Research]
日期：2025-07-03
卷期号：85 (17): 3207-3218
标识
DOI：10.1158/0008-5472.can-24-3662
摘要
Development of a mouse model of RIT1M90I-altered non-small cell lung cancer reveals that RIT1M90I is a driver of lung tumorigenesis and that RIT1-mutated tumors are sensitive to MAPK pathway inhibitors. See related commentary by Wu and Vaishnavi, p. 3186 See related article by Mozzarelli et al., p. 3196.
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