纳米化学
检出限
银纳米粒子
盐酸盐
拉曼散射
金属有机骨架
基质(水族馆)
分子
纳米颗粒
金属
材料科学
线性范围
核化学
纳米技术
化学
拉曼光谱
组合化学
色谱法
有机化学
吸附
地质学
物理
光学
海洋学
作者
Yanru Ding,Yuqi Cheng,Baoqin Hao,Lin Zhu,Nan Zhang,Bing Zhao,Yuan Tian
标识
DOI:10.1007/s00604-021-05008-4
摘要
A versatile surface-enhanced Raman scattering (SERS) assay has been established that can realize rapid and sensitive determination of sildenafil (SIL) and pioglitazone hydrochloride (PIO) adulteration in healthcare products. Metal–organic frameworks-silver nanoparticles (MOFs-AgNPs) with SERS activity were successfully prepared via in situ synthesis AgNPs on the MOFs surface. By virtue of the adsorptivity of MOFs, the MOFs-AgNPs could effectively concentrate the drug molecules on the electromagnetic enhancement areas of AgNPs. Moreover, the MOFs-AgNPs substrate exhibited more sensitive SERS activity than classical AgNPs with linear range of 1.0 × 10–7–1.0 × 10–5 mol L−1 for SIL and 8.0 × 10–7–3.0 × 10–5 mol L−1 for PIO and limit of detection (LOD) of 4.8 × 10–8 mol L−1 for SIL and 1.4 × 10–7 mol L−1 for PIO. The designed method realized the determination of SIL and PIO in commercial tablets and healthcare products with recoveries of 93.8–108.0% and 93.0–104.0%, respectively, with relative standard deviation (RSD) of 2.7–4.1% and 2.2–4.2%, respectively. The present system displayed little interference effect on determination. This work provides a multifunctional route for the determination of other drugs via the SERS technology.
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